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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e7e99b854d671322a161d2d3fcea39ebe9fdd12c3aa258a678129a32c15cd5' 
  AND token = 'Pw7Aq1j1nF9xP8/KtxjNIsP1eXKjuL4J8piSCG1hUEk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}