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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10543b9c7a7ab2f73a549bb17c0afd4c161a9a04796e5dd16c7191af867803d0' 
  AND token = 'tUdj/BvAKXcNr5TtzQC4jlhFPJAQiPSdUKPRsZcrr5w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}