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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8108c2a227e4a65e5d316942db4ee3ce781a9d0ccc7a906ea7468af8aad2ef0d' 
  AND token = 'Pgp3OLK1Zk30eDtmQ8uM9FKANESSVLUFY4VMT0ZYq4A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}