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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d376134390a0f816399a7af0fc418e751c4b161a56bfd0f5783e1f8eda3f8f1' 
  AND token = '+M/kKE5SVzcRYS/5KgtU799SepcIZMud07IfENKV21Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}