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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4244a37bf731aab5b28d03c9d5e2daf82088025b00df62c9985f9f0f55db9720' 
  AND token = 'xV1TIWR8B54OxL8jH3N6aBMUVgZaSxtpzTfTjXEbohM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}