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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3cd21011877c79234a069a6384ea62cb1918b0f3ed1b56c15272d5d4585559a' 
  AND token = 'xB3t4QIarxIhanKtE+udBm7WXdm6WG7BQWKtjf0ZLQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}