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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64ff51bc0f3bf14d286078d53da1351172844b5b25bc25e87e0389f3d41b531c' 
  AND token = 'MB2SnZFrXirgnbQ+T5SwW4WOrK8pUk0poaO/X3X5Yzg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}