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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221493374289fa2ca6a26a3dcaaf7d7e2a382b03b28dc4650b728de83d226160' 
  AND token = 'IzaoBKC3S/PJH5gSejSZcMVSErz7xl8/RWywPvFJLgo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}