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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649e365c656254c2eb7458a73cc333b1736be7880c8e9edd860d11a10dc4ab37' 
  AND token = '3athyAGDi5drEYCEscSW1x+cDmQRYCkMvcAQqt4rhao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}