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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a563cff2991051fb0f0c05c14c0eb4cac0a89be937d6ad056b51adc26d3df44' 
  AND token = 'eR4qlhXXB1XnBl2qGw7pBQrVkkMuxOSCOHMdC3rmGfk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}