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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80b321c3b8fefa405d70ed60764b9e1cf386c91fab628ccb9eeab19450b0b2a6' 
  AND token = 't3ccxyWiwBTM67yL/6tBwLbPmruAZxTTJW4BO8jKrKw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}