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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72260add0d8f1b5f1b57fca56398e0affafdcb6f5fc28d2f7b77ea1be74cac78' 
  AND token = 'VgAPyR2bJB9lURADjZ59+kO68pVhGXfT54pOjOTWyeE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}