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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f289e5d2356b88cf3a4fdcfe9a3d7127cc257c0b339a841221d1214a4d897c43' 
  AND token = '1XRMmbu1cD3RBf0KVOwAcVasYA0WCoCEvFEhFFc6R/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00050

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}