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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8244b46285c6880c18235f358bbb2424ba511c55b5b698a4580cd71f6afde86f' 
  AND token = 'myQRP3Sk4QuOKqlTvLt5BFIIfTz0+292dmMcGkANxnc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}