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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0fa2cf25ab52156d1e1091b8cce8e0bc3f70ab842d6e27b842e4540337cfe971' 
  AND token = 'Z38osYOU+I3HyA5xG5cFRJHvVNjD02UnRHaKt0PTPII=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}