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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c5f5344d06d9fa27385f514e12b96b203c64d9ca8111c0b5fc594691607087' 
  AND token = '8r6M3a18XBicbSFOy22syygGkNYKPcSXtCgkzygRZPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}