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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2144178dfed92b0d2c35c379139d32ff68f16bb467dfca2f6dbf0f18ce186709' 
  AND token = 'LSfLndOV4Vgc95Rk/R++jWeoN+LpdPoCdTHtkygoNV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}