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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25d4a86bde260e112245e08df68e95a2a0b24587425d015e18ffdbf56cc6d1b1' 
  AND token = 'Gva7Ij0qG0OIECFQeRD/grU+aQS1FPBk0ZD9EgfMSQA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}