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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65e4a9139276ffa2678604272a70607757674e8927aa40c1912b0bf0ce1c0c4b' 
  AND token = '8bX9QEfKPnFg00P0KIem5DjXuS+EKSZGKmNYhDyk6ww=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}