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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e8e818a370955d3500ad345b33addeb967d5d4e2aa4c06ee3cb791370a099d9' 
  AND token = 'MtXkpEsf5c5mtWF+Ft3UsjWsYGrMxTU/VGmO2Bpr4rc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}