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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78426b38dafe05413951c47adb9dd705611c4089dde527faf7b0bc89200e72a5' 
  AND token = 'D6B7hLJantanFfCGA/DmimMbk87VJUUx51xgKMSHEnY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}