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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb8717c51f8cca6ca3aefb74e62e63f7d6c859cec630224d6055f00afedf9e28' 
  AND token = 'ZjtCVRgxB3CiRGCi1IymUXTRoX9T7wTAh7+aBbqzlIs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}