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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '95b74d3e682aaf294d3a8f3da5c461f12438d2f74d6f4da583f4575583f57d0a' 
  AND token = 'cy1Ar/X0zc2q4cT1JFVtmZYgh/IAept/Y+63tm6yEmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}