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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '31f014435be54989a3f50fdd6d80ff728d5cfd16439d596d64087fb6012f4821' 
  AND token = 'nIOgUMaty08YIcWOBl0O6v0CsPs4p7DRn3NZouc5Afg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}