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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '160211331cc95fbed49eae54731b1012d61a252425b5bf9e5da4723a26fa2033' 
  AND token = 'oEgKIhRXMJzfxMW9Het58bs5NHLehrKFEORR4uCNqcA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}