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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '071b6d922b66a66a9012dca45545ee179d064e21a1922d48fb1574c032c41bed' 
  AND token = 'iw3I0lebQTMaX/W1CuOaImLWE3dPYwC8GvsqRlIMREY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}