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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5d8673f78c2710d4284e00095d936bb9b0a37709791a9165d6e315c8f5b3d10' 
  AND token = 'v8rpuaEXdPGj0U7lP5EQdQb3Xvq6BOLfTzmDePgX5zs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}