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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d03b78d8b9915a7b4e80c6865445964316a2efcb8fdc03faf75bf6d7d3dbb30' 
  AND token = 'Wv9FpTWn7AxR4f86znU2IDDuhPtXj3MQ/MkZP25gAPU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}