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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '344f2e14939767ac89e3acb0369d2c14f1ee600cb5a0a6b5ed667a4bcde25b03' 
  AND token = '/+MtdMEBFXz2+zkUGw1KI2Lc0eHFSvBHjNTBSpb3/DI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}