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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2266879f66a83ccad1d579730287d108535b7c6b75012b30c683c70af237fced' 
  AND token = 'zRf+4PrOqOiD1TJc29zcp7BXmIqahXbBg0pklIf5kdQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}