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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a5b015b1c89c69f0d26845ef192a7917128a07aa99f3bece58a74287d6e2295' 
  AND token = 'eB0Cw4I3tSTo1pQnT09JAOpuD8teWqRyg975c+vQuG4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}