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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b4b0873f4e320a539ed35c2ec1991bbe44ba1bb280a1da633dcf8cafa625001' 
  AND token = 'u7QyLlhK5JO7YxDJ/4g19ZVhnYUbZ5kCQ00xy41RgNw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}