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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb7356a441634e8f663d7d3c1a63d60cb2169f749f393278e493c35d4bab5e22' 
  AND token = 'KjOeeqjumHCxrC9d7bvxSd/oFKM+3TgGEj+jWGeECk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}