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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '23d95afc8b8c8cd22515eba643d60e6b1838d7d16f821235bbfb36a99b0d1057' 
  AND token = 'XqFy3onRLMK7i6kBbT+IsC7Ng2hKgvqvSdGeFCxMdig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}