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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b4b7a13a16f4dd8b06c601df5becd1c8d4e148cb3f142ec3dc267c14b66e36a' 
  AND token = 'OEcYEmIoqFslT90/LFkGFhHoa9XpS/AJf0Um5gdH00A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}