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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12220234e74ad59d39c8017b2b3ed88828ac272c1ec2c442bf1801c0d8490a55' 
  AND token = 'PjIQ+3HQbpcHdeA4FSGSzZl4lPeGq3uWzl6NGpY88Kg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}