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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80c3988449da5b4e7eb1b8f27ed2610055e1e352beb2cac4d28df9e300758a95' 
  AND token = 'nEP4/Zad1v6KLKaoPmHhh+YdmjLybnx5A0DfrIMAMdI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}