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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eb00a6d0035210269f057d5c2569eebe3cf701a07a9b220dfdb3215e07640a83' 
  AND token = 'ru65kx9GmPmu0eblR0qYLn6cXHTunkx607raIYH6dFw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}