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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e81d9a1366b0810136263f359131e1caec58cbf4dfc8ca557a002a887334fdf' 
  AND token = 'P/ZynYAg6Zf1PrQRNYm2JWIIUPxxMWMp9siNYx/LXyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}