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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b06382bb350abf04f3a1beaaae1fc8299dda365ee0800918ff7c076dd86654' 
  AND token = 'ZicjoiDpxscLGcw+FGIrNxhr8nG9MZvttzywBkMCheU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}