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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81e87680a439bd255d5b0083fde021ba3614ff464539fd4d8e2385361a5d0780' 
  AND token = 'yzetabrThJgVONTUnzhx5JhCjiN9STAF2bo1DtqFdKA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}