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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '347c6c0f94f3409518aee754f82edc871cb028943df0a1fc7af6311e65b1be6a' 
  AND token = 'uU9/8t6bONAkeNTpxbRRgQLxoFEHmcgYlFPT5ZE/lW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}