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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '851257c24d0c6cc5d8aa18b82bcc312b2327f2854ece273c9cc7117bbecd5760' 
  AND token = '1//GH7Uqu9DRBlOSjJl0pHlcBcZhFTH1G9IV2IgD0a8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}