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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15fd2aecbf5dbc31bad11f5648dfc876b865192144dce1304ef6b07e795bda9d' 
  AND token = 'I/++X+peyM3FJX6c0LdUnA4DVtMNZNaCDgUkJr4EQWw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}