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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4efb2d56f517c1fd12bc47730d694a94a6024793e6cdf9f29521cb014297941f' 
  AND token = 'yOWapWUA/1bdHI+wVeTUQ0LhAmiEbNynFoyBCED+72A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}