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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5396be32e9f78066aeefc3c2c8b81f9bd0f9bd6d71d90bc7242e1b7a477f4f48' 
  AND token = 'EbtsOYs0SRz3Ut7yoIIWhJbrw7ZTpvzjB7cLFgWSny0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}