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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4421651f4164ff32be81976f1042cd3559636851beb35ac27e43defdfed022d1' 
  AND token = 'Rxb5+CZCWJEnISvMoWkBq9nsc3EuNDP15ugSAvzJP4o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}