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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b488ccdef3ee4ef92b0c1cab433cdab8d3a02f4ff4f53d5189269ada1b37a069' 
  AND token = 'o3CQ/idJ+4dgbd5eO0KiFHOtyAMGAuDHVmwEM6kYETc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}