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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '55465240d8f2a1fe794f2e25b8e14bd9b5f38b02b9a3b506bbad24e3edff9535' 
  AND token = 'EMxQZ4CsnjgW2ODovkY+DQlR4LrkmO/o68mRKZDX+hc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}