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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6947000775cce8f58c03f323841c727a9ee8b3646a79791d287d390f0150160d' 
  AND token = '+xtzHzmF8DOD7W+PPemXLkKoisVwIUzTH8Fb66HD52Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}